STRESS INDUCED NEURO-ENDOCRINE-IMMUNE SYSTEM ALTERATION AND ITS RELATION WITH AUTOIMMUNE/INFLAMMATORY DISEASES: A REVIEW

In recent years a novel scientific discipline called psychoneuroimmunology has emerged that examines complex interdependence of the mind, brain, endocrine and immune system in health disease. Homeostasis (a self-referral phenomenon) plays an important role keeping person healthy it fundamental host defense. Many studies show stress (acute or chronic) creates disorder especially regulation. this study typical nervous-endocrine network been shown case stress. From Corticotrophin Releasing Factor (CRF), Adrenocorticotrophic Hormone (ACTH), Growth Hormone(GH), prolactin (PRL), Glucocorticoids (GC) catecholamine are found as factors T cells, B monocytes/macrophages, Natural Killer(NK) cells their cytokines is Tumor Necrosis Factor-a (TNF-a), Gamma Interferon (IFN-g) interleukins such IL-1, IL-2, IL-4, IL-6, IL-10 etc. most related studies. Finally, autoimmune/ inflammatory disease relation to above factors. summary, we have demonstrated psychoneuroimmune alteration its association with autoimmune/inflammatory The present suggests importance restoring organization body.